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We did not find a correlation between serum and dermal CD4 T-cell counts in HIV-positive DRESS cases, indicating that although overall depletion of the circulating CD4+ T-cell pool is likely a major driver of this finding, several additional factors may impact individual CD4+ T-cell dermal infiltrates including CD4 cell activation and exhaustion status, migratory capacity/skin homing receptor expression and extent/duration of drug-induced antigenic stimulation

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