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Regular exercise, as a key intervention validating MQC plasticity, has been shown to partially reactivate energy-sensing and biogenesis-related pathways, promoting coordination between mitochondrial renewal and autophagic processes, thereby improving mitochondrial functional status to a certain extent ( Specifically, although aging is accompanied by reduced expression and activity of NRF2, exercise stimuli can still activate the NRF2 pathway within a certain range, promoting expression of downstream antioxidant enzymes such as catalase and superoxide dismutase