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These drugs are intended for the oral treatment of hemolytic anemia due to SCD and vaso-occlusive crisis (VOC), in adults and children aged 12 years and older [87]

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In BRAF V600E-mutant CRC, tumor cells often exhibit an initial response to BRAF inhibitors, but frequently develop resistance through reactivation of the MAPK pathway, commonly via KRAS amplification or MEK mutations [76]