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Disruption of MAM composition or aberrant MAM formation is linked to various pathologies, notably neurological and cardiovascular diseases [51,52,53] Together, these pleiotropic mitochondrial functions underscore how subtle perturbations in organelle structure or activity can disrupt cellular homeostasis and contribute to the pathogenesis of numerous diseases
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A strong jet of water striking the powdered lyophilizate directly can mechanically damage (denature) the sensitive peptide structure
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