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In rodent models overexpressing human tyrosinase, the extracellular NM activates microglia, leading to their phagocytosis and degradation of the pigment, which indicates an active neurodegenerative process ( Evidence also shows that the progressive build-up of NM over time in SN dopaminergic neurons may induce abnormal misfolding of α-syn ( 2.2 Lipid peroxidation in PD Abnormal lipid metabolism and subsequent lipid peroxidation are pivotal pathological features commonly observed in PD and ferroptosis