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Due to the similarity in the structure between dopamine (DA) and METH, METH can enter the presynaptic cellular compartment through the dopamine reuptake transporter (DAT), where it can subsequently enter synaptic vesicles through VMAT2 and resultant DA release into the cytoplasm [55-57]
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A feature of neuroinflammatory responses includes the expression and activation of the Nod-like receptor protein 3 (NLRP3) inflammasome, particularly in the context of AD and PD
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