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Consistent with a role for ROS, the administration of dimethylthiourea (DMTU), a non-specific scavenger of hydroxyl radicals, prevented the effects of cisplatin on renal mitochondrial redox state, bioenergetics and oxidative stress [95,96]

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The Mitochondrial Disruptor Devimistat (CPI-613) Synergizes with Genotoxic Anticancer Drugs in Colorectal Cancer Therapy in a Bim-Dependent Manner