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This does not prevent pharmacodynamic overlap (both compounds have effects lasting well beyond 2 hours) but does reduce the chance of peak-effect stacking, where maximal sedation from diphenhydramine coincides with the acute post-injection window for BPC-157

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10.1073/pnas.1415518111 [DOI] [PMC free article] [PubMed] [Google Scholar] 9.Kagan VE, Tyurin VA, Jiang J, Tyurina YY, Ritov VB, Amoscato AA, Osipov AN, Belikova NA, Kapralov AA, Kini V, et al