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Furthermore, the NNMT SNP rs694539 increases risk of acute lymphoblastic leukemia ( NNMT is expressed mainly in the liver and adipose tissue, and a small amount of NNMT can be detected in the kidney, lung, skeletal muscle, and the heart ( NNMT expression is altered in metabolic diseases such as obesity and cirrhosis ( Association Between NNMT Expression and Poor Cancer Prognosis Considering that NNMT is elevated in various cancers, most studies on NNMT have focused on its early diagnostic role ( In addition to being used in early diagnosis, NNMT is also related to poor prognosis