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Mitochondria also participate in the generation and removal of reactive oxygen species (ROS), maintain intracellular calcium homeostasis, initiate specific apoptotic pathways, and synthesize a variety of metabolic intermediates ( Increasing evidence indicates that mitochondrial dysfunction is an early and key driver of OA, particularly chondrocyte degeneration ( This review aims to systematically examine the basic research evidence for mitochondrial-targeted therapies for OA, providing an in-depth analysis of potential mechanisms of action, key targets, and candidate drugs/strategies