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The deficiency incidents also increase with age, as well as in individuals with gastrointestinal disorders, vegans and chronic patients undergoing therapy with proton pump inhibitors, H2 antagonists or metformin [22,23,24]
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Studies with the antidotes N -acetylcysteine (NAC) and methionine, revealed that whereas NAC was able to prevent and reverse the toxicity of APAP in phase 2, methionine was essentially without effect, despite the fact that both were effective in phase 1
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