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Polmacoxib is an orally active dual inhibitor of COX-2 and carbonic anhydrase (CA)

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Discussion 1) The results of this study completed by McCoy et al systematically evaluated the metabolic stability, BBB permeability, procognitive activity, and synaptogenic potential of Dihexa and other Nle¹-AngIV analogs, ultimately aiming to identify a therapeutic agent for dementia