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In general, B12 treatment for a minimum of 2 months improves signs and symptoms in all patients with SCD, while Romberg’s sign and mild sensory disturbances in the toes and fingers may persist in some patients after several weeks or months of B12 therapy [7,89]

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For example, high-dose folinic acid (1–2 mg/kg/day) has shown promise in improving language skills, especially in children with folate receptor alpha autoantibodies