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The peptide translocates to the nucleus under metabolic stress, where it regulates AMP-activated protein kinase (AMPK) signalling and modulates expression of genes involved in glucose and lipid metabolism

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In one trial, obese patients receiving Contrave-32 [BUP (360 mg/d) + NTX (32 mg/d)], along with a diet and exercise regimen, experienced a mean weight loss of 8.1%, compared to only 1.8% in the placebo group