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According to a genomics database, which examines entire gene sets of humans, SLC12A8 is expressed in humans “…with highest levels in small intestine, stomach, testis, thyroid, and colon.” Thus, the possibility exists this NMN-specific transporter is expressed similarly in the gut of humans and has a similar role in NMN absorption as well

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SIM1 haploinsufficiency causes hyperphagia, obesity and reduction of the paraventricular nucleus of the hypothalamus