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Studies have shown that brief co-incubation of sperm with endometrial EVs enhances the acrosome reaction, elevates reactive oxygen species (ROS) levels, and stimulates protein tyrosine phosphorylation, all indicative of capacitation

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Some non-mammalian models have also been used to understand the mechanisms behind CIPN, such as Zebrafish or Drosophila models, and these are described in detail in another review within this Special Issue