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doi: 10.1016/S1470-2045(14)70420-6 8 ShitaraKDoiTDvorkinMMansoorWArkenauHTProkharauAet al

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The role of autophagy in cancer appears paradoxical: in some settings, it is tumor suppressive, by limiting oxidative stress and chromosomal instability that may lead to oncogenic mutations 123, 124 , while in other situations, autophagy supports cancer cell survival by providing nutrients and suppressing stress pathways such as p53 125, 126