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As illustrated in Figure 4, the gut microbiota serves as a central hub in diabetic lung injury, where gut-derived metabolites and toxins (e.g., LPS, BCAAs) remotely regulate pulmonary inflammation and immune responses through systemic circulation, ultimately leading to endothelial disruption and oxidative stress

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Recently, some meta-analyses by Koumaras and colleagues revealed potentially less favorable effects of atenolol on central pulsatile hemodynamics