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On the other hand, activation of pro-survival GsPCRs adenosine-A2-receptor (A2R), calcitonin-gene-related-peptide-receptor (CGRPR), or relaxin-family peptide-receptor 1 (RXFP1) results in protective effects on cardiomyocyte survival as a function of cAMP generation by AC6, resulting in activation of cAMP efflux pumps