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In fact, mass spectrometry (MS/MS) sequence analysis indicated that the underlying molecular cause of diminished GPx-1-specific activity was a conversion of Sec to dehydroalanine (DHA) by β-elimination (loss of H 2 SeO 2 ) after excess hydrogen peroxide-induced oxidation of Se-OH to SeO 2 H (69)
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[DOI] [PMC free article] [PubMed] [Google Scholar] 34.Luo M, Shang L, Brooks MD, Jiagge E, Zhu Y, Buschhaus JM, Conley S, Fath MA, Davis A, Gheordunescu E, Wang Y, Harouaka R, Lozier A, Triner D, McDermott S, Merajver SD, Luker GD, Spitz DR, Wicha MS