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Sleep deprivation and circadian misalignment have opposite effects on cortisol Acute total sleep deprivation increases cortisol levels Chronic circadian misalignment reduces 24-hour cortisol levels Chronic circadian misalignment increases TNF-α, CRP and IL-10 levels Acknowledgments Supported by NASA Cooperative Agreement NCC9-58 with the National Space Biomedical Research Institute and NASA, by NIH RO1 HL081761 and R21 DK092624

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The rat jejunum luminal contents and mucosal homogenates were extracted from euthanised rats at the University of Auckland (12–18 months prior)