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“It’s much less potent than GLP-1s, but the muscle-sparing effect is important,” as one-third of the weight lost on GLP-1s is muscle mass

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NAD+ Preservation and Sirtuin Activation First and most directly, NNMT activity consumes nicotinamide, which is a key precursor for NAD+ biosynthesis through the salvage pathway (the predominant NAD+ synthesis route in most mammalian cells)