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This enzyme dephosphorylates guanosine triphosphate (GTP) to produce cyclic guanosine 3′,5′-cyclic monophosphate (cGMP), which activates K + channels and inhibits Ca 2+ entry into smooth muscle cells by directly inhibiting voltage-gated Ca 2+ channels, and activates protein kinases that phosphorylate myosin light chains and phosphorylate sarcoplasmic proteins, leading to the sequestration of Ca 2+ in the sarcoplasmic reticulum (153-154)
