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Phase 2 clinical trial data published in the New England Journal of Medicine in 2023 demonstrated substantial mean reductions in body weight — in some participants exceeding 20% over 48 weeks — alongside improvements in glycaemic control and cardiometabolic markers
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![Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD5305): A PARP1–DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs](https://pubs.acs.org/cms/10.1021/acs.jmedchem.1c01012/asset/images/medium/jm1c01012_0016.gif)
