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PAB also reduced GSH levels via the p53-mediated xCT pathway, increasing H 2 O 2 and lipid peroxides

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This enzyme contains a carboxyl domain with homology to TRX that appears to act as a functional GRX, as it uses GSH to reduce adenosine 5′-phosphosulfate to sulfite with apparent K MGSH values of 0.6 to 1 mM (Bick et al., 1998)