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It has been hypothesized that the PCB neuronal deleterious effects could be related in part with the formation of one of their phase I metabolites, the hydroxyl-PCB produced by cytochrome P450 monooxygenases (Fonnum and Mariussen, in vitro by the rat UGT1A6 isoform which is expressed in brain (Daidoji et al., In conclusion to this part, brain tissue is able to glucuronidate various xenobiotics which can cross the BBB
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