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found that active GSH metabolism within tumors further suppresses immune responses, such as IFN-γ signaling and PD-1/PD-L1 interactions, while reducing the number of M1 macrophages and increasing the proportion of M2 macrophages

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Cell-based assay datasets additionally describe its engagement with nitric oxide-mediated signalling systems and its modulatory effects on extracellular matrix protein expression in standard cell culture model systems