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Data extraction was based on the common research elements included in the articles
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available only through 503A compounding or research supply SNRI drugs covered / venlafaxine (Effexor XR) and duloxetine (Cymbalta) Primary interaction concern / overlapping serotonergic and vasopressive effects DDI severity grading / not classifiable (no human PK/PD interaction studies exist) Serotonin syndrome incidence with SNRI monotherapy / estimated 0.07 per 1,000 patient-years per pharmacovigilance data Venlafaxine CYP pathway / CYP2D6 (major), CYP3A4 (minor) Duloxetine CYP pathway / CYP1A2 (major), CYP2D6 (moderate) BPC-157 CYP interaction profile / unknown in humans
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