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The CCSS and an SJLIFE cohort study investigated the contribution of cancer-predisposing variants to the risk of SMN-related late mortality (5 years or more after diagnosis).[40] Among 12,469 participants (6,172 male and 6,297 female), including 4,402 from the SJLIFE cohort (median follow-up time since collection of first biospecimen, 7.4 years) and 8,067 from the CCSS cohort (median follow-up time since collection of the first biospecimen, 12.6 years), 641 (5.1%) carried cancer-predisposing variants
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