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Semaglutide weight loss mechanism #1: it prevents blood sugar spikes Well-functioning L-cells located in the gut produce natural GLP-1 after food intake, which inhibits potentially damaging postprandial glucose excursions (PPGEs) – in laymen’s terms, post-meal blood sugar spikes (PPG inhibition is why, before the FDA approved GLP-1 analog semaglutide for weight loss therapy, it was commonly used in the treatment of diabetes.) This blood sugar-limiting effect mediated by a complex interplay of hormones is called “glucose homeostasis.” Semaglutide, a GLP-1 analog, does the same thing to regulate glucose homeostasis, but with greater efficacy due to the concentrated dosage used in therapy