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In vivo and in vitro studies demonstrate that activation of Nrf2 reduces fibrotic progression by upregulating antioxidant enzymes such as heme oxygenase-1 (HO-1) and NAD(P)H quinone dehydrogenase 1 (NQO1), thereby countering reactive oxygen species (ROS) accumulation in lung tissues (Dong et al., 2022
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