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As one of the main source to produce H 2 S in retina, 3-MST in hyperglycemic cells fail to convert 3-MP to H 2 S when the extracellular glucose concentration is elevated, and thus lost the ability of stimulating angiogenesis or cell proliferation, but the proangiogenic effect by exogenous H 2 S is not attenuated by hyperglycemia 112

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