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doi: 10.1016/s0925-4439(02)00074-1

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CARTILAGE AND JOINT REGENERATION Chondroprotective Effects: Notable Discovery: Stimulation of chondrocytes: increased proteoglycan synthesis 40% Type II collagen: upregulation of 35% expression GAGs (glycosaminoglycans): increased production of 50% Cartilage matrix: improves structural integrity Osteoarthritis Models Cartilage degradation: reduced loss in the 35% group compared to controls MMPs: decreased MMP-13 (collagenase) 45% Synovial inflammation: reduction in infiltrate 40% Pain: Improves behavioral pain scores 30% Proposed Mechanisms: IGF-1 / GH: Direct chondrocyte effect Inflammation modulation: reduction of joint IL-1β, TNF-α Cartilage anabolism: favorable synthesis/degradation balance 4

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