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Briefly, we generated mice with RBC-specific ablation of BPGM ( eBpgm –/– mice) by mating Bpgm f/f mice with epoR-Cre mice (for details, see the Materials and methods) and compared RBC function and aging-related phenotypes, including primarily cognitive ability, muscle function, and glucose tolerance, between the control ( Bpgm f/f ) and eBpgm –/– mice at 4 and 15 months of age (Fig

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This work was supported by the KU ADRC Brain Health Training Program P30 AG072973