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In white adipose tissue of obese, insulin-resistant and aged mammals, NNMT is dramatically upregulated — and because it consumes both the universal methyl donor (SAM) and the NAD⁺ precursor (nicotinamide), its hyperactivity simultaneously depletes the cellular methylation reserve and the NAD-salvage pool [1,2]

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In most cases it is considered safe to take supplements through injections to make up for this deficiency, but if you want to know more about it then this article is for you