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Ferroptosis can be triggered by GSH depletion, which can be achieved by inhibiting GSH biosynthesis (e.g., buthionine sulfoximine (BSO) inhibits γ-glutamylcysteine synthetas (γ-GCS)) or blocking the uptake of cysteine from the extracellular environment (e.g., erastin inhibits the Xc − system) [126, 127]

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Two community patterns circulate for humans: a low-dose oral pattern (250 mcg to ~1.5 mg once daily) using small-strength vendor capsules, and a higher pattern anchored to the supplier's 50 mg tablet (1 tablet daily)