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A 2015 clinical study by Kannt, Pfenninger, and colleagues published in Diabetologia measured NNMT mRNA in white adipose tissue and plasma 1-methylnicotinamide (MNA) concentrations across 314 participants (199 surgical patients, 60 enrolled in an exercise intervention, 55 undergoing bariatric surgery) and found that plasma MNA correlated significantly with WAT NNMT expression in patients with type 2 diabetes and that plasma MNA was inversely correlated with insulin sensitivity

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Most clinical trials have shown it is well accepted by most patients and the side effects have mostly been negligible and very few have occurred