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Cyclooxygenase 2 augments osteoblastic but suppresses chondrocytic differentiation of CD90(+) skeletal stem cells in fracture sites
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Concretely, the accumulated lactate promotes CIRP lactylation and consequently leads to CIRP release in macrophages, which then binds to ZBP1 in pulmonary vascular endothelial cells (PVECs)
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