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If we compare B12 adenosylcobalamin with the synthetic cyanocobalamin form, conversion seems to be the biggest potential issue when it comes to bioavailability and absorption: all forms of B12, once ingested, have to be broken down to their core cobalamin molecule, but cyanocobalamin will have to be transformed into adenosylcobalamin and methylcobalamin first

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Post-bariatric patients also benefit from bypassing gut limitations