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As extensively documented by George Brooks and others, nearly all pyruvate is converted to L-lactate under ordinary circumstances, and there is some evidence that lactate dehydrogenase is often physically connected to GAPDH to facilitate the immediate conversion of NADH back to NAD+ so that the NAD+ needed for the GAPDH reaction continues in rapid supply
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Nat Protoc 1 , 3159–3165 (2006)
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