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Eight states do not allow medical assistants to start a patient IV at all: Alaska, California, Connecticut, Florida, Mississippi, New Jersey, New York, and Texas

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studied CCl4-exposed mice and found that metformin reduced the expression of TGF-β1 and inhibited the TGF-β1/Smad3 pathway, thereby inhibiting the expression of fibroblast genes and fibroblast markers such as α-SMA and E-cadherin directly mediated by Smad3 (68–70)