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In summary, the NF-κB signaling pathway is critical in the process of GABA exerting its role in regulating neuroinflammation on macrophages, astrocytes and microglia, and may be a key therapeutic target for inhibiting neuroinflammation and improving insomnia diseases

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Damaged hepatocytes release ROS into the extracellular environment, thereby activating ROS-generating hepatic stellate cells