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EMB is necessary for definitive diagnosis
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13 According to Global Burden of Disease (GBD) 2021 data, hemoglobinopathies and hemolytic anemias (including carrier states such as G6PD trait, sickle cell trait, and thalassemia trait) collectively affect an estimated 27,789.88 per 100,000 population globally, and these disorders represent a potentially substantial but poorly quantified contributor to the worldwide PAH burden
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