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A 2019 Cochrane-style systematic review of growth-hormone secretagogues in elderly adults found that secretagogue-driven IGF-1 elevation consistently improved lean body mass (weighted mean difference approximately 1.0-1.5 kg over 12-24 months) but did not significantly reduce fracture incidence or all-cause mortality across trials [10]
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The CREDENCE trial enrolled 2,627 patients with type 2 diabetes and albuminuric kidney disease [urinary albumin-to-creatinine ratio (UACR) 300–5,000 mg/g
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