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Although, to date, a complete understanding of physiological conditions that may create reductive stress have not been elucidated, conditions, such as hypoxia, hyperglycemia, and other stresses that inhibit mitochondrial function, are known to cause excess accumulation of cellular reducing equivalents (199, 270, 358)

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Minoxidil: clinical evidence and Research This is the section where the comparison becomes most lopsided, and it's important to be straightforward about it