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Dapsone : used to treat leprosy, dermatitis and Pneumocystis jirovecii pneumonia 5 Non-antimicrobial sulfonamides include Hydrochlorothiazide and furosemide : act as a diuretic and help control blood pressure Glyburide : used to lower blood sugar levels Celecoxib : a non-steroidal anti-inflammatory drug (NSAID) used to reduce pain and inflammation 4 Mechanism of sulfa drug As competitive inhibitors of the dihydropteroate synthetase (DHPS) enzyme, antibacterial sulfonamides target the bacterial metabolic pathway