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For example, ROS can activate nuclear factor kappa B (NF-κB), a key transcription factor that regulates the expression of pro-inflammatory cytokines, chemokines, and adhesion molecules [134]

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This imbalance is marked by Drp1 hyperphosphorylation at Ser616, which amplifies fission activity, whereas suppressed MFN2 expression and aberrant OPA1 processing impair fusion, resulting in widespread mitochondrial fragmentation (Massaad and Klann, 2011