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Further studies will examine differentiation-specific differences in the metabolic pathways that directly impact the clearance and/or shunting of NA into the NAD + salvage pathway

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A recent study reported that the Km values of NNMT for NAM and SAM was 20 ± 3 μM and 24 ± 6.8 μM via SAH hydrolase (SAHH)-coupled fluorescent assay [16], which was quite different from those documented in previous literature