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They utilized small molecules (for example OTV1 (2-[5-(2,3-dihydro-1,4-benzodioxin-6-yl)-1 H -indol-3-yl]ethan-1-amine), OTV2 (2-(5-phenoxy-1 H -indol-3-yl)ethan-1-amine)) and Nitro-I (2-(5-nitro-1 H -indol-3-yl)ethamine hydrochloride)) that were close analogs of 5-HT agonists as probes and observed their coupling preferences to provide an insight into the structural basis of functional selectivity

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