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Within the realm of bone tissue engineering, this microenvironment comprises both osteogenic and immune cell lineages, including mesenchymal stem cells (MSCs) and pre-osteoblasts as the principal osteogenic cells, and macrophages as the dominant immune cells ( The complexity of the bone defect microenvironment makes cells vulnerable to various factors during regeneration and repair, creating substantial challenges for bone healing and clinical implementation of bone tissue engineering
![Biochemical Pathway of Pheomelanin and Eumelanin Synthesis [31–35]](https://www.researchgate.net/publication/384768350/figure/fig1/AS:11431281286228337@1729907538195/Biochemical-Pathway-of-Pheomelanin-and-Eumelanin-Synthesis-31-35-Abbreviations-DHI.png)
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